Humans have a salamander-like ability to regrow cartilage in joints, new research suggests.
Cartilage in human joints can repair itself through a process similar to that used by animals such as salamanders and zebrafish to regenerate limbs, scientists have found.
The study identified a mechanism for repair that appears to be more robust in ankle joints and less so in hips.
Researchers say the finding could potentially lead to treatments for osteoarthritis, the most common joint disorder in the world.
Professor Virginia Kraus from the departments of Medicine, Pathology and Orthopaedic Surgery at Duke University Medical Centre in America was the senior author.
“We believe that an understanding of this salamander-like regenerative capacity in humans, and the critically missing components of this regulatory circuit, could provide the foundation for new approaches to repair joint tissues and possibly whole human limbs,” she said.
The scientists devised a way to determine the age of proteins using internal molecular clocks integral to amino acids, which convert one form to another.
Newly-created proteins in tissue have few or no amino acid conversions, while older proteins have many.
Understanding this process enabled researchers to identify when key proteins in human cartilage, were young, middle-aged or old.
According to the research published in Science Advances, the age of cartilage largely depended on where it was in the body.
Cartilage in ankles is young, is middle-aged in the knee and old in the hips.
This correlation between the age of human cartilage and its location in the body aligns with how limb repair occurs in certain animals.
The scientists say their discovery also suggests why hip and knee injuries take longer to heal, and often develop into arthritis.
The researchers also found that molecules called microRNA regulate this process, and are more active in animals that are known for limb, fin or tail repair, including salamanders, zebrafish, African fresh water fish and lizards.
They believe microRNAs could be developed as medicines that might prevent, slow or reverse arthritis.
“We believe this is a fundamental mechanism of repair that could be applied to many tissues, not just cartilage,” lead author Dr Ming-Feng Hsueh, said.
Australian Associated Press