Tag Archives: Postpartum

Timing of Postpartum Depression Onset May Predict Symptom Pattern

Postpartum depression (PPD) is a common and complicated illness, affecting about 15% of women in the perinatal period. Recent research from the PACT consortium (Postpartum Depression: Action Toward Causes and Treatment) has sought to classify the many potential subtypes of this heterogenous illness and has found emerging differences in time of onset, severity, comorbid anxiety,… Read More »

Opioid Use in Pregnant and Postpartum Women: Resources and CDC Expert Commentary

According to a recent analysis of national data by the Centers for Disease Control, the number of pregnant women with opioid use disorder (as documented at the time of delivery) more than quadrupled from 1999 through 2014. Studies of opioid exposure in pregnancy suggest increased risk for adverse pregnancy outcomes including stillbirth, higher rates of… Read More »

Oral Allopregnanolone Analogue for Postpartum Depression Treatment

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD).  SAGE-547, now called brexanolone, is a neurosteroid, an analogue of allopregnanolone and an allosteric modulator of GABAA receptors.  Since that time, Sage Therapeutics has conducted three randomized controlled trials, enrolling a total of 247 women diagnosed… Read More »

Postpartum Care in the United States: Some Progress But Still So Far to Go

Earlier this year the American College of Obstetricians and Gynecologists (ACOG) released a revised Committee Opinion calling for a new paradigm for postpartum care in the United States.  Moving away from the single postpartum check at 6 weeks, ACOG has made a significant change in its recommendations for postpartum care: “All women should ideally have… Read More »