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Route, Onset of Action, Peak Effect, Duration of Action Diprivan injection should be prepared for single patient use only, just prior to the initiation of each procedure. Flumazenil (Romazicon) will reverse the respiratory effects of diazepam overdose . Hydromorphone has a strong analgesic action and antitussive activity. Duration of sedative effect is 3 hours; this may be prolonged up to 90 hours in elderly patients and in patients with hepatic or renal dysfunction. Anticonvulsant effect is 30 to 60 minutes after I.V. ebogdan.eug: hydromorphone. Aug 25, - hydromorphone hydrochloride (Dilaudid) IV push Onset of action 10 to 15 minutes and lasts 2 to 3 hours. Indication: .. diazepam (Valium) IV.

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